Despite advances in acne therapy in recent years, treatment failure is common. The aim of this study was to investigate the efficacy of low daily dose isotretinoin in moderate to severe acne patients. The secondary objective was to measure the rate of relapse 5 years after the completion of therapy. In this retrospective, noncomparative study, patients with moderate to severe scare prone acne. Liver function tests serum glutamic-oxalocetic transaminase, serum glutamate pyruvate transaminase, direct and total bilirubin, and lipid profiles total cholesterol, low-density lipoprotein, high-density lipoprotein, triglyceride were evaluated for all patients, before the initiation of treatment and again after the 2 nd month of treatment. At the end of treatment course, All adverse effects were mild, and discontinuation of treatment was not necessary.

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In general, most people do see improvement within 1 to 3 months of isotretinoin treatment. The response does depend on the initial severity, dose of treatment and individual factors. In some individuals, there may be an initial outbreak before it gets better. You are on 40mg of isotretinon which is a fairly high dose. This can cause a lot of dryness of the lips and face. Using products containing benzoyl peroxide can certainly cause the skin to be more irritated and dry. I think it is best to stop applying this if you are experiencing skin dryness and tightness. It is good to continue with moisturizers to calm the irritation.

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Correspondence Address : Dr. There is a paucity of comparative data on the various low-dose regimens of oral isotretinoin in the Indian literature. Objectives: To assess and compare the efficacy and tolerability of two low-dose oral isotretinoin treatment regimens 20 mg daily and 20 mg alternate days in moderate to severe acne vulgaris. Results: A total of patients completed the study. At the end of therapy, decrease in the total acne loads up to While in the moderate acne, significant difference in the response between both groups was observed only up to 12 weeks.

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It reduces the amount of oil released by oil glands in your skin, and helps your skin renew itself more quickly. As it dries out oil glands, patients experience severe dryness of their skin and mucous membranes. Accutane is used to treat severe nodular acne. It is usually given after other acne medicines or antibiotics have been tried without successful treatment of symptoms. Because it can cause severe, life-threatening birth defects, many doctors are hesistant to use it. Never use Accutane if you are pregnant or planning pregnancy.

Isotretinoin is a treatment for severe acne that your doctor can prescribe if other measures haven't helped. Isotretinoin is only available on prescription. It comes as 5mg, 10mg, 20mg and 40mg capsules. Isotretinoin belongs to a group of medicines known as retinoids, which are derivatives of vitamin A. When you take isotretinoin by mouth it works by reducing the production of the skin's natural oil sebum.

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Accutane ruined my life. I took 80mg of Accutane for 9 months 18 yrs old. So my derm recommended this. Side effects: dry skin all over, chapped lips, eczema, brittle nails. Vision problems, waking up in morning 20mg accutane my eyes sealed shut with pus, and dry eyes.

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It is also used to prevent certain skin cancers squamous-cell carcinoma, and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. Its isomer, tretinoin, is also an acne drug. The most common adverse effects are a transient worsening of acne lasting 1—4 months, dry lips cheilitis, dry and fragile skin, and an increased susceptibility to sunburn. Uncommon and rare side effects include muscle aches and pains myalgias, and headaches. Isotretinoin is known to cause birth defects due to in-utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development.

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