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Tonicclonic seizures are major convulsions involving spasm of all muscles. There is loss of consciousness and possibly incontinence. The abnormal brain activity involves the whole of the cerebral cortex.

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Sale and supply of medicines by podiatrists. The most common side effects of imidazoles are irritation and itching of the skin. Some imidazoles are known to interact with oral hypoglycaemic drugs by enhancing their activity and they may increase the risk of myopathy with lipid lowering drugs statins. Some imidazoles enhance the anticoagulant properties of warfarin. However, these interactions are unlikely with topical application. Systemic administration of imidazoles is often necessary for tinea of the nail.

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