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However, in about a third of patients with Parkinsons disease dementia eventually develops. Parkinsons disease is a disorder of the basal nuclei in the brain. Post-mortem studies of brains from patients with Parkinsons disease have shown greatly decreased levels of dopamine in the basal nuclei. The main pathology is degeneration of the dopaminergic neurons of the pathway from the substantia nigra in the brain stem to the corpus striatum (the nigrostriatal tract). Parkinsons disease was the first disease to be associated with deficiency of a specific neurotransmitter in the brain.
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Environmental factors that may play a role in the aetiology of Parkinsons disease include: living in a rural environment; using well water; exposure to pesticides; a diet high in animal fats or carbohydrates; or low consumption of foods rich in antioxidants such as vitamin C and E. Rarely, Parkinsonism can also follow head injuries, cerebral tumours and cerebral ischaemia.
29.02.2016
Edeltraud
Verified
It has a duration of action of about Repeated injections have been shown to produce tachyphylaxis; that is successive administration produces a reduced effect. Lidocaine may be used with adrenaline to increase its speed of onset and prolong its duration of action.
14.07.2017
Joachim
Verified
Anti-cholinergic drugs were originally used prior to the development of levodopa because many signs of excessive parasympathetic activity are seen in Parkinsons patients (salivation, sweating and incontinence).
25.03.2019
Maximilian
Verified
As part of the pain management plan was to rationalize medication while the patient waited for his epidural therapy, a consultant pain physician was called to confirm diagnosis.
08.08.2020
Bettina
Verified