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Increasing the blood supply by applying heat or massage will increase the rate of absorption. Conversely, for a local effect, addition of a vasoconstrictor to the injection decreases the rate of removal of the drug from the site of injection.
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Distribution to the rest of the body depends on how well a drug can pass across cell membranes. Some drugs can be sequestered in certain tissues, particularly fat and muscle.
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Hence, proprietary names have been avoided in this book except where the proprietary name is in common usage.
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