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The site of action is in the brain, probably the medulla, and the effect is to reduce sympathetic output. Examples of centrally acting antihypertensives are methyldopa and clonidine.
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Eczema is a localized inflammatory reaction in the skin that has several possible causes.
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Central side effects with long-term therapy of levodopa can be serious enough for treatment to be stopped. These include dyskinesias, restlessness, anxiety, confusion, disorientation, insomnia or a schizophrenia-like syndrome.
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