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Zidovudine is a thymidine analogue and was the first drug introduced that inhibits reverse transcriptase. This action terminates the growing viral DNA strand.
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It is therefore important for health care professionals to have an understanding of therapeutic uses of medicines, normal doses, adverse effects, interactions with other drugs, precautions and contraindications.
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It induces liver enzymes, which reduces its effectiveness and the effectiveness of other drugs such as phenytoin, oral contraceptives, warfarin and corticosteroids.
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Administering medicines, especially by IV routes, was therefore considered a postregistration activity.
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