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Adverse reactions include the risk of acute renal failure due to blockage of tubules because contrast agents are relatively insoluble. Adequate water intake by the patient is essential to reduce the risk of renal toxicity. In some high-risk patients or in emergency situations, renal toxicity can be prevented by the use of acetylcysteine. This is possibly because of its antioxidant properties. However, it is probably better to use alternative methods of investigation, for example ultrasound in high-risk patients. The common conditions predisposing to high risk of renal toxicity with contrast agents are listed below: Pre-existing renal failure Serum creatinine above Hypovolaemia Ventricular dysfunction Hypertension Dehydration Nephrotoxic drugs Diabetes mellitus with renal impairment Advanced age Multiple myeloma Any patient requiring high dose Toxicity is also related to chemical composition of a contrast agent.

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