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Chloroquine inhibits digestion of haemoglobin by the parasite and both drugs inhibit the disposal of haem, which is toxic to the parasite. falciparum is resistant to chloroquine in most parts of the world. This appears to be due to decreased uptake andor increased removal of the drug from the parasite. Quinine is now the main drug used against P. falciparum malaria. Chloroquine is still effective against other forms of malaria.


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In addition treatment aims to prevent destruction of joints by the use of disease-modifying antirheumatic drugs. Indeed, use of DMARDs early on in the disease process is now recommended.

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