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Clonazepam, sold under the brand Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and the movement disorder known as akathisia. Common side effects include sleepiness, poor coordination, and agitation. Clonazepam was patented in and went on sale in in the United States from Roche. Clonazepam is prescribed for short term management of epilepsy and panic disorder with or without agoraphobia. Clonazepam, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects. Clonazepam has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of clonazepam. Clonazepam has been found to be effective in the acute control of non-convulsive status epilepticus ; however, the benefits tended to be transient in many people, and the addition of phenytoin for lasting control was required in these patients. It is also approved for treatment of typical and atypical absences seizures, infantile myoclonic, myoclonic, and akinetic seizures. The effectiveness of clonazepam in the short-term treatment of panic disorder has been demonstrated in controlled clinical trials. Some long-term trials have suggested a benefit of clonazepam for up to three years without the development of tolerance but these trials were not placebo -controlled.

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How Clonazepam works Clonazepam is a benzodiazepine. It works by increasing the action of a chemical messenger GABA which suppresses the abnormal and excessive activity of the nerve cells in the brain. Swati Mishra. Khushbu Goel. Zapiz Intas Pharmaceuticals Ltd. Clonotril Torrent Pharmaceuticals Ltd.

Inclusive of all Taxes. This medication is an anticonvulsant, muscle relaxant, prescribed for Lennox-Gastaut syndrome, panic disorder and seizures. It decreases abnormal electrical activity in the brain. Seizure Disorders- Adults: The initial dose should not exceed 1. It may be increased if needed. Pediatric Patients: The initial dose should be between 0.

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Normally, binding of acetylcholine to its receptor triggers muscle contraction. These drugs produce a short-lasting paralysis that can be reversed by anticholinesterase drugs. They have no sedative action or analgesic effects. Examples of non-depolarizing neuromuscular blockers are pancuronium and atracurium. Side effects of non-depolarizing neuromuscular blockers are mainly caused by histamine release and include flushing, increased heart rate, hypotension and bronchospasm.

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