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It is good practice for the pharmacist to make the patient or their representative aware at the outset that they will not be able to collect the balance of a Schedule 2, 3 or 4 CD after the 28 day period has elapsed. Instalment dispensing via EPS is not yet possible. The only changes that pharmacists can make are Where an amendment is made by one pharmacist and another pharmacist makes the supply, the Home Office has advised that the second pharmacist should also mark the amendment to indicate that he is also satisfied and it is attributable to him as well. This only applies to Schedule 2 CDs. Pharmacists have the discretion to decide whether to ask for proof of identity and also whether to supply the CD.

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Thus, each receptor has two binding sites and both must be occupied for the receptor to be activated. Receptors for some other neurotransmitters, for example gamma-aminobutyric acid and glutamate, are believed to be similar.

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Evidence against this serotonin theory includes the fact that low levels of ( have recovered and in some patients buy clonazepam uk mania. It seems likely that low levels of serotonin or noradrenaline do not cause depression, but that more complicated mechanisms involving a change in balance between these monoamines are involved. Despite evidence for and against, there remains one major problem with the monoamine theory of depression. All antidepressants take weeks to have an effect, which is far longer than it takes to alter brain amines. It has been suggested that effects of antidepressants are due to adaptive changes in the brain, which may involve down regulation of receptors or some other change in their sensitivity. Some of the newer types of antidepressants do not facilitate monoamine transmission at all.


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