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Common side effects include daytime sleepiness, headache, nausea, and diarrhea. Zolpidem is a nonbenzodiazepine Z drug which acts as a sedative and hypnotic. Zolpidem was approved for medical use in the United States in Zolpidem is labelled for short-term usually about two to six weeks treatment of insomnia at the lowest possible dose. It can be taken if there are at least 4 hours between the time of administration and when the person must be awake.

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These drugs were known as dangerous drugs but are now referred to as controlled drugs. The use of controlled drugs for medicinal purposes is permitted by the Misuse of Drugs Regulations and subsequent amendments. The regulations define classes of people who are authorized to supply and possess controlled drugs during the course of their professional activities. Controlled drugs are divided into five Schedules by the Regulations. Exhaustive regulations govern the safe custody of controlled drugs.

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