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Extended formulary nurse prescribing was discontinued in nurse independent prescribing. Nurses can now prescribe any licensed medicine, including some controlled drugs, if they are qualified to do so.

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In this way, trimethoprim interferes with the conversion of folate into its activated form, which is a cofactor in the synthesis of bacterial DNA. Dihydrofolate reductase also occurs in host cells, but it is less sensitive to trimethoprim.

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