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While the definition of a PGD is straightforward, local interpretation has allowed them to be used creatively in a wide range of circumstances. It is important that all podiatrists and their employers, understand the scope and limitations of PGDs as well as the wider context into which they fit when designing safe, effective services for their patients. In summary, PGDs are most suitable when the use of medicines follows a predictable pattern and is not tailored for individuals with complicated conditions. They are generally most appropriate to manage a single treatment episode or series of episodes of the same condition.

When a drug is administered, it does not achieve an equal concentration throughout the body. Unless a drug is injected directly into the blood stream it will be absorbed from its site of administration, then enter the systemic circulation and be transported to the tissues in plasma. The body can be considered to be made up of aqueous and lipid compartments. Lipid compartments include all cell membranes and adipose tissue. Aqueous compartments include tissue fluid, cellular fluid, blood plasma and fluid in places like the central nervous system, the lymphatic system, joints and the gastrointestinal tract. The distribution of a drug into these different compartments depends on many factors.

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