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On release they cross the synaptic cleft and bind to receptors on the post-synaptic neuron. Binding of neurotransmitter with its receptor is very brief, but it brings about stimulation or inhibition of the post-synaptic neuron. See Figure transmission. The events that take place at a synapse, that is synthesis of neurotransmitter, storage in vesicles, release, interaction with receptors and eventual inactivation provide targets for drug action. Inactivation of a neurotransmitter can be by re-uptake into the neuron it was released from, or by the action of enzymes in the synaptic cleft. NB While the exact involvement of a particular neurotransmitter in a particular CNS disorder is unknown, a question mark denotes more uncertainty about the neurotransmitter involvement.

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Glucophage price canada

Chemotherapy also applies to treatment of cancers. Cancer cells are similar to normal cells and most anticancer drugs show little selective toxicity and therefore produce serious adverse effects.

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Drugs that decrease the effectiveness of sulfonylureas include diuretics and corticosteroids. There are three other groups of drugs licensed in the United Kingdom for the treatment of NIDDM.

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If bone pain is severe or if the patient has neurological symptoms, or fractures that will not heal, calcitonin or bisphosphonates may be indicated. Calcitonin is the natural hormone that inhibits the activity of osteoclasts.

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They provide an alternative for those who cannot tolerate ACE inhibitors because of a persistent dry cough, but should not be used in pregnancy either.

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