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In addition, this group of drugs causes metabolic disturbances, particularly insulin resistance and hyperglycaemia, and fat redistribution leading to raised plasma lipid levels, which increases the risk of heart disease. These effects are collectively known as lipodystrophy syndrome, which appears to be similar to what happens with long-term corticosteroid use. All drugs in this group inhibit liver enzymes and cause interactions with many other drugs. In particular, they increase the risk of myopathy with statins. Some antiviral drugs in this group act by blocking an ion channel that allows the release of genetic material from viruses once they are inside the host cell and which allows viral particles to leave the infected host cell to infect other cells.

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