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One form is Hashimotos thyroiditis, an autoimmune condition where antibodies are produced against thyroglobulin.

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In addition, through an effect in the central nervous system cardiac glycosides cause an increase in parasympathetic activity and therefore slow conduction through the AV node, hence their usefulness in atrial flutter and atrial fibrillation. However, cardiac glycosides have a very low therapeutic ratio and can be very toxic.

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