Risk of myopathy: Increased by coadministration with fibrates, niacin, cyclosporine, macrolides, combinations of HIV protease inhibitors eg, saquinavir plus ritonavir, lopinavir plus ritonavir, tipranavir plus ritonavir, darunavir plus ritonavir, fosamprenavir, and fosamprenavir plus ritonavir, or azole antifungals. Temporary therapy discontinuation recommended for patients with acute surgical or medical conditions, elective major surgery, or serious condition suggestive of a myopathy or risk factor predisposing to development of renal failure secondary to rhabdomyolysis. Rare reports of immune-mediated necrotizing myopathy IMNM, characterized by increased serum creatine kinase that persists despite discontinuation of statin. SLCO1B1 polymorphism is thought to have a lesser effect on the more hydrophilic statins eg, rosuvastatin, fluvastatin compared with those that are more lipophilic eg, atorvastatin, simvastatin. Other genetic polymorphisms of elimination eg, CYP, P-glycoprotein for each individual drug must also be considered, to explain variability for statin clearance among patients that exhibit SCLO1B1 polymorphism.

Abstract This 6-week, double-blind clinical trial evaluated lipid parameter responses to different dosages of atorvastatin in patients with primary hypercholesterolemia. After completing an 8-week placebo-baseline dietary phase, 81 patients were randomly assigned to receive either placebo or 2. Previously, reductions in LDL cholesterol of the magnitude observed in this study have been seen only with combination drug therapy. In this study, atorvastatin was well tolerated by hyperlipidemic patients, had an acceptable safety profile, and provided greater reduction in cholesterol than other previously reported HMG-CoA reductase inhibitors. The risk for coronary heart disease CHD, the number one cause of death in Western societies, is increased in individuals with elevated concentrations of plasma LDL cholesterol. Although several types of lipid-regulating drugs are available, combination drug therapy may be necessary in some patients to achieve target plasma cholesterol levels.

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Healthcare Ireland. Atorvastatin calcium trihydrate. Product subject to medical prescription which may be renewed B. Legal category: Product subject to medical prescription which may be renewed B. Section 4. Improved presentation of SPC uploaded. Section 5.

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Lipitor can also raise the levels of HDL cholesterol good cholesterol in your blood. The drug is sometimes prescribed to people with an existing heart condition to lower their risk of experiencing a heart attack or other cardiac event. Additionally, Lipitor may be prescribed as a preventive drug for people with type 2 diabetes, high blood pressure hypertension, a history of smoking, or other conditions that could increase their risk for heart complications. In, the company denied liability for lawsuits by women who claimed that Lipitor gave them type 2 diabetes, stating that the women may have other risk factors that make them vulnerable to the disease, such as high blood pressure or obesity. In a study of more than, patients newly treated with a statin, researchers found that Lipitor presented the highest diabetes risk. Additional studies reported that diabetes risk is higher for certain groups, including the elderly, women, and Asians.

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Current evidence indicates that statins increase the risk of new onset diabetes mellitus NOD and also deteriorate the glycemic control in patients with known diabetes mellitus DM after high-dose statin therapy. Study 2 vs baseline Baseline: 7.

Efficacy of atorvastatin when not administered daily. Mailing address. Although they are indicated for daily use, some doctorsgive prescriptions for every other day, mainly with the purpose of reducing costs. After a week diet period, atorvastatin was initiated at a dose of 10 mg per day. The percentage variation in costs was the parameter to evaluate the saving. Forty one patients remained throughout the study and had their weekly dosage reduced.

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Lipitor is a prescription drug used to lower bad cholesterol and reduce the risk of stroke, heart 20 mg lipitor, and other heart and blood vessel problems. Food and Drug Administration approved the medication in Its active ingredient is atorvastatin calcium. By lowering the amount of LDL in the blood, the medication prevents atherosclerosis, a condition in which plaque deposits accumulate on the inner walls of arteries, causing them to stiffen and narrow. In turn, this reduces the risk of atherosclerosis complications like heart attack, stroke, chest pain and aneurysms.

Back to Medicines A to Z. It's used to lower cholesterol if you've been diagnosed with high blood cholesterol. It's also taken to prevent heart disease, including heart attacks and strokes. Your doctor may prescribe atorvastatin if you have a family history of heart disease, or a long-term health condition such as type 1 or type 2 diabetes or rheumatoid arthritis. This medicine is available on prescription only. It comes as tablets, including chewable tablets for people who have difficulty swallowing.

UK Edition. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. This includes any possible side effects not listed in this leaflet.

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