Before using this medication, tell your doctor if you have liver disease, or if you use a steroid or another diuretic. Avoid becoming overheated or dehydrated during exercise and in hot weather. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Spironolactone is a potassium-sparing diuretic water pill that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is used to diagnose or treat a condition in which you have too much aldosterone in your body.

Spironolactone is a potassium-sparing diuretic. The drug may also be used in combination with other medications to treat precocious early puberty and myasthenia gravis, a neuromuscular disease. Though spironolactone has been around for over 25 years, the FDA is still updating the drug's safety labeling. The development of acne lesions is associated partly with increased sebum secretion, which can be stimulated in women by androgen excess. Because of its anti-androgen activity, spironolactone is also used off-label to treat female-pattern hair loss and hirsutism.

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Spironolactone is an aldosterone receptor antagonist that acts in the renal distal tubule and collecting ducts, decreasing the reabsorption of sodium and water and decreasing the excretion of potassium. Spironolactone can be used in combination with other diuretics, primarily furosemide, to produce additional diuresis generally a mild increase or to decrease potassium excretion. In addition, as an aldosterone antagonist, spironolactone is considered a neuroendocrine modulator aldosterone receptor blocker. Spironolactone is also used in the management of fluid retention associated with noncardiac disease such as hepatic disease and nephrotic syndrome. Spironolactone might be particularly useful as a diuretic in the setting of right heart failure causing ascites. Vito M. Campese MD, Ravi S.

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Long-term maintenance therapy for patients with discrete aldosterone-producing adrenal adenomas who are not candidates for surgery or for patients with bilateral micro or macronodular aldactone 2 mg hyperplasia idiopathic hyperaldosteronism. Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

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Common side effects include electrolyte abnormalities, particularly high blood potassium, nausea, vomiting, headache, rashes, and a decreased desire for sex. Spironolactone was discovered in, and was introduced in Spironolactone is used primarily to treat heart failure, edematous conditions such as nephrotic syndrome or ascites in people with liver disease, essential hypertension, low blood levels of potassium, secondary hyperaldosteronism such as occurs with liver cirrhosis, and Conn's syndrome primary hyperaldosteronism. The most common use of spironolactone is in the treatment of heart failure. The classification of spironolactone as a potassium-sparing diuretic has been described as obsolete. Spironolactone has antiandrogenic activity.

What is spironolactone, and how does it work mechanism of action? Aldactone spironolactone is a potassium-sparing diuretic that removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease. It also can be used in combination with other drugs to treat diuretic-induced low potassium hypokalemia and high blood pressure. Aldactone also is used to counteract the effects of excessive adrenal aldosterone production hyperaldosteronism that can occur from a tumor in the adrenal gland or enlarged adrenal glands hyperplasia of the adrenal glands. What are the uses for spironolactone? What are the side effects aldactone tab 25 mg spironolactone?

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Spironolactone is a potassium-sparing diuretic and selective aldosterone blocker used off-label in dermatology for treatment of aldactone 2 mg and hirsutism in women. When used for the treatment of acne and hirsutism, the mechanism of action of spironolactone is not completely understood. Spironolactone seems to affect androgen receptors in the sebaceous glands causing reduced sebum production and thereby causing an improvement in acne symptoms. Aldactone is the original branded preparation and is FDA approved for the management of primary aldosteronism, edematous conditions e. Spironolactone is not FDA approved for the treatment of acne or hirsutism. It should only be considered for the treatment of acne or hirsutism in select women when androgen sensitivity is suspected to be contributory or for women in which other acne treatments have been ineffective or insufficient.

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Spironolactone is a potassium sparing diuretic like eplerenone that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered. Label Off label uses of spironolactone involving its antiandrogenic activity include hirsutism, female pattern hair loss, and adult acne vulgaris. Spironolactone was developed in, marketed in, and approved by the FDA on January 21, A governmentally-recognized ID which uniquely identifies aldactone 2 mg product within its regulatory market. Spironolactone has antiandrogenic activity which leads to many of its off label uses.

Unnecessary use of this drug should be avoided. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. Establishing the diagnosis of primary hyperaldosteronism by therapeutic trial. Short-term preoperative treatment of patients with primary hyperaldosteronism. Long-term maintenance therapy for patients with discrete aldosterone -producing adrenal adenomas who are judged to be poor operative risks or who decline surgery.

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