Spironolactone is used in combination with other medicines to treat high blood pressure hypertension and heart failure. Lowering blood pressure can reduce the risk of strokes and heart attacks. Spironolactone is also used to lessen the need for hospitalization for heart failure. Spironolactone is a potassium-sparing diuretic water pill. It prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

Common side effects include electrolyte abnormalities, particularly high blood potassium, nausea, vomiting, headache, rashes, and a decreased desire for sex. Agonists Cations incl.

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Spironolactone is a potassium sparing diuretic like eplerenone that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered. Label Off label uses of spironolactone involving its antiandrogenic activity include hirsutism, female pattern hair loss, and adult acne vulgaris. Spironolactone was developed in, marketed in, and approved by the FDA on January 21, A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

Spironolactone is a potassium-sparing diuretic. The drug may also be used in combination with other medications to treat precocious early puberty and myasthenia gravis, a neuromuscular disease. Though spironolactone has been around for over 25 years, the FDA is still updating the drug's safety labeling. The development of acne lesions is associated partly with increased sebum secretion, which can be stimulated in women by androgen excess. Because of its anti-androgen activity, spironolactone is also used off-label to treat female-pattern hair loss and hirsutism.

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Unnecessary use of this drug should be avoided. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. Establishing the diagnosis of primary hyperaldosteronism by therapeutic trial. Short-term preoperative treatment of patients with primary hyperaldosteronism. Long-term maintenance therapy for patients with discrete aldosterone -producing adrenal adenomas who are judged to be poor operative risks or who decline surgery. Long-term maintenance therapy for patients with bilateral micro or macronodular adrenal hyperplasia idiopathic hyperaldosteronism.

Sep 27, It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. If you have any concerns about taking this medicine, ask your doctor or pharmacist. Keep this leaflet with the medicine. To treat essential hypertension high blood pressure with an unknown cause.

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Potassium-sparing diuretic; used for edema, ascites, HTN, hypokalemia, acne vulgaris, polycystic ovary syndrome, female hirsutism, and to diagnose primary hyperaldosteronism; also improves survival and NYHA functional class, and reduces aldactone 25 mg tablets in NYHA Class IV heart failure. Continue treatment for at least 2 weeks since the maximum response may not be observed until this time. Subsequently, adjust dosage according to patient response. The American Academy of Pediatrics AAP recommends that diuretics be used as add-on therapy in patients unresponsive to other antihypertensive drugs. Allow 72 hours between dosage adjustments due to the gradual onset of action. Titrate dosage as needed every 2 weeks.

This consultant podiatrist is using supplementary prescribing in primary care, mostly with older patients many of whom are living in nursing homes. She prescribes from a personal formulary of drugs within her own area of competence. In practice, this means that the majority of her prescribing is for antibiotics and dressings for the treatment of infected diabetic foot ulcers. The consultant podiatrist is a member of a rapid access referral team for the treatment of patients with serious skin ulcers. As a team, they use Scottish Intercollegiate Guidelines Network (SIGN) guidelines for antibiotic therapy.

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