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They are used to enhance radiological examination of parts of the body not normally visualized by X-rays, by providing a greater contrast of structures such as blood vessels, ducts and hollow organs of the body. Such contrast agents are based on iodine or barium because these particular atoms absorb X-rays well. The more radio-opaque atoms per molecule in a contrast agent, the greater the X-ray absorption is. Ideally, contrast agents should be non-toxic, should not be absorbed or metabolized and should be excreted rapidly after imaging. Iodine contrast agents are the most convenient, most effective and least toxic for general use.

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