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It is available as a Griseofulvin spray has recently been added to the list of medicines that registered podiatrists can access and supply. Oral griseofulvin is prescription-only and is indicated where topical therapy is ineffective but it has largely been replaced by the newer imidazole antifungals. Griseofulvin should be taken with or after fatty food for adequate absorption. Following oral administration, griseofulvin is sequestered into the keratin of skin and nails. Griseofulvin has to be taken for at least four weeks and because the drug may be teratogenic, it must not be used in during pregnancy, or in the month before conception or by prospective fathers six months prior to conception. Common adverse effects of oral griseofulvin are diarrhoea, nausea, vomiting, headache and photosensitivity.

Folic acid is converted into folate, which then has to be converted into an activated form by dihydrofolate reductase. In this way, trimethoprim interferes prednisolone 5mg tab the conversion of folate into its activated form, which is a cofactor in the synthesis of bacterial DNA. Dihydrofolate reductase also occurs in host cells, but it is less sensitive to trimethoprim. Trimethoprim is used to treat urinary tract infections. It is also formulated in combination with a sulphonamide, when it is known as co-trimoxazole, to treat pneumonia in patients with HIV.

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