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The abnormal product then brings about the action of the original drug.
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Toxoplasma infection is common in the United Kingdom and normally causes a mild illness that can go unnoticed. In pregnancy, it can however damage the developing foetus and may cause abortion.
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Levodopa is given orally and in order to maximize the amount that actually reaches the brain, it is given in combination with a decarboxylase inhibitor, carbidopa, which does not enter the brain. Because the drug is not converted into dopamine outside of the brain, this greatly increases the effective dose of levodopa and reduces peripheral side effects.
17.03.2016
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The pacemaker forms part of a conduction system that transmits electrical activity through the heart by means of action potentials so that contractions are coordinated and the heart can function as an efficient pump. The conduction pathway of electrical activity goes from the SA node to the atrioventricular node between atria and ventricles, then down the septum between the two ventricles to the apex of the heart and finally round the ventricles themselves.
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The mechanism is probably competition for metabolizing enzymes or displacement from plasma protein binding sites. Drugs that decrease the effectiveness of sulfonylureas include diuretics and corticosteroids.
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