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LOCAs have lower renal toxicity than HOCAs ( kg as first choice. The frequency of contrast agent injection and dose are known risk factors for renal toxicity.
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An example is sodium etidronate. Side effects of bisphosphonates are bone pain and gastrointestinal disturbances.
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However, the use of corticosteroids does depend on individual circumstances. In acute exacerbations, which could be life threatening, a high initial dose of corticosteroid can be given to induce remission.
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An inhibitor of GABA has not been identified, but it has been tentatively called GABA modulin. It is possible that the RAS can be activated through pathways from the cerebral cortex if a situation is perceived as being threatening.
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