HIV infection is treated with a combination of antiviral drugs with different mechanisms of action. Infection with fungi can be superficial affecting skin and nails, or systemic affecting internal organs, particularly the lungs. Systemic fungal infections have become more common due to overuse of antibiotics and increase in numbers of immunocompromized patients. Many antifungal drugs work by interfering with ergosterol production thus making the fungal cell membrane leaky. Others prevent fungal cells from dividing.

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And Hodgetts, A. Development of a Limited Formulary Prescribing Scheme for Therapy Radiographers and Oncology Nurses NHS Executive RD Project Grant: Ref D Conference. Further reading Health Service Circular HSC Department of Health Medicines Matters: A Guide to Mechanisms for the Prescribing, Supply and Administration of Medicines, National Practitioner Programme Department of Health Core Prescribing Group, London. Price, R.Miller, L.

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A basic knowledge of the structure of the skin is required in order to understand how disorders arise and how they can be treated. The skin consists of three layers: the epidermis, the dermis and the subcutis. Cells on the border between the dermis and the epidermis are constantly dividing and moving towards the skin surface.

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One preparation contains podophyllum, which is a cytotoxic drug and must not be used in patients who are pregnant or considering pregnancy or breast-feeding. Podophyllum inhibits cell division in virally infected cells. Treatment with wart paints is usually once or twice a day with abrasion between applications. Perseverance with treatment is essential and surrounding skin should be protected with plasters or Vaseline. Herpes simplex of the skin can be treated with acyclovir.

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