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In some circumstances, it may be advantageous to administer a drug rectally, for example if a patient is unconscious or vomiting, or uncooperative in some way, but generally, it is considered an unpleasant method. Many of the general factors considered above that affect absorption from the gastrointestinal tract apply equally to this route of administration. Sublingual administration of a drug allows the drug to go directly into the systemic circulation without first passing through the liver. This route can provide a rapid means of absorption of a drug. It is a route commonly used, for example, to treat attacks of angina with glyceryl trinitrate. Factors affecting absorption from the oral mucosal membranes include lipid solubility and molecular weight of the drug, pH of the saliva and the rate of removal by the blood as well as the application of the correct technique.
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Adverse effects include drowsiness, depression and postural hypotension especially in the elderly, which restricts their use to resistant hypertension.
16.12.2020
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Metabolism usually makes a drug more water soluble and less pharmacologically active.
26.05.2016
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The anterior pituitary gland receives releasing factors from the hypothalamus in blood via a venous portal system.
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Distribution of such drugs is widespread unless plasma protein binding is extensive.
30.09.2017
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