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An example of an anticholinesterase drug is pyridostigmine.
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Depolarization is initiated by an influx of sodium ions into the cardiac muscle cells, followed by an influx of calcium ions.
30.05.2018
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Treatment aims to enhance cholinergic transmission. The most useful drugs are central acetylcholinesterase inhibitors, for example donepezil.
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This means that for extensively protein bound drugs there will be a greater concentration of free drug than expected. This could lead to increased incidence of side effects.
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They are more effective in treatment of the immediate phase reaction than the late phase reaction. β stimulants are less effective in chronic bronchitis, possibly because in this disease bronchoconstriction is due to reflex stimulation of acetylcholine receptors following stimulation of local irritant receptors in lung tissue.
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