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Other adverse effects include megaloblastic anaemia, mild hypersensitivity reactions and osteomalacia. Phenobarbital is dangerous in overdose, producing coma and respiratory and circulatory failure and consequently is not much used nowadays.

  • Intravenous anaesthetics can be used for short surgical procedures of Their elimination from the body is too slow to allow rapid control of the depth of anaesthesia needed for long procedures.
  • Drugs have been developed to block these receptors.
  • You may find the British Thoracic Society Guidelines useful for this case study.
  • They exist in large amounts in the plasma or tissue fluid and are rapidly cleared by the liver or kidney.

This is often at odds with their intended therapeutic use, but nevertheless is what generally happens. The main route of excretion of drugs and drug metabolites is via the kidneys.

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Levodopa has been shown to produce symptoms of mania in patients with bipolar depression but not in those with unipolar depression. This still does not explain the swings in mood and little is known about how or why alternation between depression and mania occurs.

Drugs used to treat tuberculosis generic tramadol 100mg isoniazid, rifampicin and pyrazinamide primarily with streptomycin and ethambutol as secondary drugs. Viruses are made up of a protein capsule, some with a lipoprotein envelope around it, containing genetic material, with maybe a few enzymes but very little else and hence they are not considered to be cells, but, rather, infectious particles. Viruses are able to bind to cell membranes, penetrate and infect cells of other organisms. Viruses are intracellular parasites; they cannot replicate themselves without using the contents of the host cell to synthesize the cellular components necessary for their reproduction. This makes the development of effective antiviral drugs that do not damage healthy host cells very difficult. Historically, the development of antiviral drugs has been slow when compared with the development of other antimicrobial drugs.

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Calcitonin is used in the treatment of Pagets disease and osteoporosis. The adrenal glands are situated one above each kidney. They have two separate parts; an inner medulla derived from nerve tissue and an outer cortex, which is typically endocrine in structure. The adrenal medulla secretes adrenaline. They have similar physiological effects, which augment activation of the sympathetic nervous system.


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The mode of action of these two drugs is not fully understood. Chloroquine inhibits digestion of haemoglobin by the parasite and both drugs inhibit the disposal of haem, which is toxic to the parasite.

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Xanthines are of principle use in the immediate phase reaction of asthma but also have some effect on the late phase reaction.

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Benzodiazepines enhance the effects of GABA at its receptor, but they do not bring about the opening of chloride ion channels in the absence of GABA.

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It is technically more difficult but is considered to be safer and has largely replaced spinal anaesthesia. The local anaesthetic is introduced into the extradural space between the bone of the spine and the dura mater, which is filled with fatty tissue and blood vessels.

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