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We selected tramadol as a representative drug to address our objective because it is widely prescribed as an unscheduled opioid analgesic and can easily be purchased from NPOPs. As such, the geometric growth in the use of online pharmacies around the world should prompt intense medical and regulatory discussion about their role in the provision of medical care.

  • Thalassaemia varies in severity.
  • Diabetes mellitus is due to either absolute deficiency of insulin or insulin resistance and reduced insulin secretion.
  • Anxiety and fear are both associated with general arousal of the CNS and may be due to over activity in the RAS.
  • Some non-steroidal anti-inflammatory drugs are licensed for the prevention and treatment of post-operative pain.
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Deficiency of PTH is treated with injections of calcium and calcitriol (a vitamin D analogue). High levels of calcium in blood plasma cause the release of calcitonin from the thyroid gland, which inhibits the reabsorption of calcium from bone by inhibiting osteoclasts.

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They are less commonly used nowadays because modern anaesthetics are less irritant. Hyoscine is antiemetic, sedative and produces some amnesia.

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