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If a drug is to have a therapeutic effect on the body, it first has to reach its site of action. In order to do this a drug has to be administered in some way. Unless the route of administration is directly into the blood stream, the drug has to be absorbed, usually by diffusion. Once absorbed, distribution of the drug to different parts of the body follows. This necessarily includes passage through the liver. Most drugs are treated as potentially toxic substances and are metabolized by the liver.
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Inhibitory neurons in the spinal cord are activated by descending pathways from the brain. Here the transmitters are GABA and enkephalin.
- It is possible that the RAS can be activated through pathways from the cerebral cortex if a situation is perceived as being threatening.
- Bacteria have many biochemical differences compared with human cells, and some antibiotics are strikingly non-toxic to humans.
- All Trust and university-based training offered to radiographers in this area is normally on a multi-professional basis.
- It does this by inhibiting an enzyme, xanthine oxidase.
- This is similar to the mechanism of action of some antiepileptic drugs.
- Most rheumatic diseases require symptomatic treatment to relieve pain and increase joint movement using non-steroidal anti-inflammatory drugs and anti-inflammatory corticosteroids to limit or stop the inflammation.
- For example Parkinsonism and tardive dyskinesia are the result of dopamine receptor blocking in the basal nuclei.
Local anaesthetics cause varying degrees of vasodilation. The combination of a fall in heart rate and peripheral vasodilatation can result in a fall in blood pressure and fainting.
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Sor. orgmemberseffective-practicepres rad newsnews A physiotherapy perspective of non-medical prescribing is discussed here.
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This is similar to the mode of action of the antifungal drug, flucytosine.
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Gerlinde
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The main disadvantage of this route of administration is that most drugs do not taste nice.
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Enteral means to do with the gastrointestinal tract and includes oral and rectal administration.
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Often bacteria in the large intestine digest the conjugate releasing free drug, which can then be reabsorbed and recycled by the process of enterohepatic shunting.
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