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  • For example, general anaesthetics are highly lipid-soluble drugs.
  • This effectively cuts down the surface area for gas exchange and results in more air remaining in the lungs during exhalation.
  • In essence, a PGD allows a range of specified health care professionals, including podiatrists, to supply andor administer a medicine directly to a patient with an identified clinical condition without them necessarily seeing a medical prescriber.
  • Analgesia is the absence or relief of pain.
  • For the best chance of success, drugs must be used early on in a patients treatment along with irradiation or surgery when the cancer is most curable and the patient is most able to tolerate treatment.
  • Examples of tricyclic antidepressants include imipramine and amitriptyline (for use of amitriptyline in neuropathic pain.

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Use of antibiotics is covered in more detail in Chapter Asthma is a disease characterized by chronic inflammation and hypersensitivity of the bronchioles leading to obstruction of the airways. Often the condition is mediated by the immune system through inhalation of an antigen to which the individual is allergic. The antigen reacts with IgE attached to the mast cells in the lung causing the release of pharmacologically active mediators. These mediators include histamine and prostaglandins together with a range of other substances in small quantities (for example leukotrienes). The immediate effects are due principally to the action of histamine and include hyper-responsiveness and constriction of bronchial smooth muscle and inflammation of bronchial epithelium. Both of these effects combine to produce an increase in airway resistance, that is, a narrowing of the airway and difficulty breathing out.

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It is not known how widespread the use of PGDs is within the therapy community, but an unpublished national survey of radiotherapy service managers indicated that radiographers were involved in the administration of medicines using PGDs. In accordance with national advice, the survey revealed that more than half of them had been trained in-house while the remainder had attended a university-based post-registration programme. The care of patients in pre-treatment (for example contrast-based X-ray examinations) also offers scope for the use of PGDs similar to those for diagnostic radiographers, but again it is not known how widespread this is. The philosophy of supplementary prescribing is well suited to the management of therapy patients. Cancer is a chronic condition and it is highly feasible to set up a CMP between the independent prescriber and supplementary prescriber (therapy radiographer). In many respects, supplementary prescribing is better than PGDs and the values of this mechanism with respect to toxicity management are indicated below: PGDs are inflexible, being restricted to specific medicines at specific doses.


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Nephrogenic systemic fibrosis has been linked with the use of gadolinium contrast agents.

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