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Such abnormalities may be the result of head trauma, stroke or tumours, but in most cases, the cause is unknown. However, it seems that abnormalities in partial epilepsy are different to those in generalized epilepsy. The choice of drug depends on the type of epilepsy. Combination therapy with two or more drugs may be necessary. In this case, careful monitoring is needed because unpredictable interactions between antiepileptic drugs are possible.

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There is a general increase in metabolism of carbohydrates, fats and proteins together with an increase in oxygen consumption and heat production. Thyroid hormone also has an influence on growth by potentiating the effects of growth hormone and on skeletal development by affecting the action of parathyroid hormone and calcitonin. Calcitonin is secreted by the thyroid gland in response to high levels of plasma calcium. Hypersecretion of thyroid hormone occurs in Gravess disease due to autoimmune stimulation of the thyroid gland mimicking the effects of TSH. Symptoms are high metabolic rate, increased temperature and sweating, nervousness, tremor, tachycardia, increased appetite and loss of weight, goitre and protrusion of the eyeballs (exophthalmia).

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