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These are the newer drugs used to treat schizophrenia. Atypical anti-psychotic drugs are recommended for newly diagnosed schizophrenics and those who cannot tolerate other drugs or who are not getting adequate control from other drugs.

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GABA receptors are found on chloride ion channels at inhibitory synapses in the CNS, including the RAS (see Figure When chloride channels open, chloride ions flow inwards making the neuronal membrane hyperpolarized. This means that there is a reduction in impulses passing on to other parts of the brain and this effect normally produces a reduction in anxiety and wakefulness. Benzodiazepines enhance the effects of GABA at its receptor, but they do not bring about the opening of chloride ion channels in the absence of GABA. Because of the existence of benzodiazepine receptors, it seems likely that there must be either an endogenous benzodiazepine or an endogenous anxiolytic substance, although none has been conclusively identified yet. For treatment of anxiety, benzodiazepines such as diazepam and oxazepam are used because they have a slower onset of action with a longer duration than others.

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Nurses can now prescribe any licensed medicine, including some controlled drugs, if they are qualified to do so.

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