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Along with ACE inhibitors, β-blockers used to be first choice drugs for hypertension (in the absence of asthmacardiac failureinsulin dependent diabetes) either alone or together with diuretics. However, they are no longer recommended except in younger people who are intolerant to ACE inhibitors and as add-on therapy if other drugs do not reduce blood pressure sufficiently.

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When used prophylactically, tolerance may develop to the vasodilator effects of nitrates. To avoid this, patients have to have drug free periods each day, when they know they are least likely to suffer and angina attack.

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Benzodiazepine anxiolytics have been prescribed to almost anyone with stress-related symptoms, unhappiness or minor physical trauma. This kind of use is now considered unsuitable.

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