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Lactic acidosis. Date of revision of the text. Concurrent administration of corticosteroids can exaggerate this effect. The product is not recommended for children under 2 years of age. Salbutamol administered intravenously has a half-life of 4 to 6 hours and is cleared partly renally and partly by metabolism to the inactive 4' -O-sulfate phenolic sulfate which is also excreted primarily in the urine.

The only toxic effect was an increase in neonatal mortality at the highest dose level as the result of lack of maternal care. There is an increased risk of hypokalaemia if high doses of theophylline or high doses of corticosteroids are given with higher doses of salbutamol. Bronchodilators should not be the only or main treatment in patients with severe or unstable asthma. Salbutamol 4 mg Tablets BP.

Active ingredient salbutamol sulfate. Respiratory, thoracic and mediastinal disorders. Administrative Data. Severe asthma requires regular medical assessment including lung function testing as patients are at risk of severe attacks and even death. Severe exacerbations of asthma must be treated in the normal way. Administration of drugs during pregnancy should only be considered if the expected benefit to the mother is greater than any possible risk to the foetus. Musculoskeletal and connective tissue disorders.

No special requirements. At therapeutic doses it acts on the beta-2 adrenoceptors of bronchial muscle providing short acting hours bronchodilation in reversible airways obstruction. Marketing authorisation holder 8. Owing to the hypokalaemic effect of beta-agonists, concurrent administration of serum potassium depleting agents known to exacerbate the risk of hypokalaemia, such as diuretics e.

Cardiac disorders. Pregnancy Administration of drugs during pregnancy should only be considered if the expected benefit to the mother is greater than any possible risk to the foetus. For the relief of bronchospasm in bronchial asthmas of all types. Metabolism and nutrition disorders. Attention should be paid to assessment of symptoms such as dyspnoea and chest pain, as they may be of either respiratory or cardiac origin.

The majority of a dose of salbutamol given intravenously, orally or by inhalation is excreted within 72 hours.

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Inactivation of a neurotransmitter can be by re-uptake into the neuron it was released from, or by the action of enzymes in the synaptic cleft. NB While the exact involvement of a particular neurotransmitter in a particular CNS disorder is unknown, a question mark denotes more uncertainty about the neurotransmitter involvement. In the peripheral nervous system, transmission of information from neuron to neuron or effector is relatively simple but in the CNS, neurons are arranged into complicated systems and pathways.

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What would the regular three-monthly blood test be for and what is the significance of the next blood test being in a weeks time. What are the usual signs of lithium toxicity. One of the drugs, valproate, is normally prescribed for epilepsy. Mr Davies is aware of this and asks you to explain why he has been prescribed it because he is pretty sure he does not have epilepsy.

Composition The active ingredient of Asthalin Tablet 4mg is Salbutamol 4mg. Some patients may experience other side effects.

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