Disorders of the CNS can be divided into psychiatric disorders and neurological disorders, although the distinction is not always clear. Psychiatric disorders include types of depression, schizophrenia, anxiety and insomnia and attention deficit hyperactivity disorder. Neurological disorders include epilepsy and Parkinsons disease, dementia and Alzheimers disease. In order to have some understanding of the nature of diseases of the CNS and the treatments available, it is necessary to have a basic knowledge of the brain and neurotransmitters that are involved in the transmission of information within the nervous system. The human brain is a complex organ made up of over as many glial cells.

Older anti-psychotic drugs are classified according to their chemical structure, while the newer ones are known as atypical anti-psychotics. The main distinction is that the newer drugs produce fewer motor side effects. Phenothiazines were developed after it was noticed that the antihistamine, promethazine had a sedative action.

Pharmacology is also the study of the toxic effects of drugs and chemicals in the environment. All drugs are capable of being toxic and all drugs can produce unwanted effects at high doses, or if used incorrectly. The difference between a medicine and a poison is often merely a matter of concentration.

Lamotrigine is similar in action to phenytoin. It appears to work on sodium ion channels to cause inhibition of the release of excitatory amino acids. Lamotrigine is considered to be first-line treatment for generalized and partial seizures and is considered more appropriate than valproate for women of childbearing age. Adverse effects of lamotrigine are similar to phenytoin.

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This can be due to deficiency of vitamin B for formation of erythrocytes. Vitamin B the stomach and is essential for absorption of vitamin B of impaired absorption due to disease of the small intestine. Oral replacement of vitamin B by intramuscular injection of hydroxycobolamin, a form of vitamin B Folic acid deficiency can occur due to pregnancy, malabsorption syndromes or inadequate diet. Some drugs, for example phenytoin, oral contraceptives and isoniazid, can cause reduced absorption of folic acid. Oral replacement therapy with folic acid is effective.

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Buy more and save! Yes No. Itching of the anal area, may sometimes be intense, especially at night when the female worms are laying eggs Mild nausea Disturbed sleep visually seen the worms in your stool. Sudden pain in the abdomen, sometimes with sickness Pain in the upper abdomen Bleeding from the bottom Problems urinating.

Metronidazole - for certain infections Cimetidine - for excess stomach acidity. Although this treatment kills the adult worms it doesn't kill their eggs, so it's really important to be very scrupulous with hygiene, even after you've taken the treatment. This will help avoid you swallowing eggs which will then cause a new infection. Measures to take include: Washing your hands and scrubbing under the nails after going to the toilet, and before preparing or eating food.

Keeping fingernails short and clean and avoiding biting your nails or sucking fingers. Do you understand that for this treatment to be effective, all members of your household need to take the treatment even if they don't have any symptoms? We need to ensure that this medicine is suitable for the person it is intended for. You will seek medical advice if you experience any side effects of treatment, if you start new medication or if your medical conditions change during treatment.

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The pKa of a drug molecule is the pH at which the drug is different drugs. Chemically, most drugs are either weak acids or weak bases. In an acidic environment, as in the stomach, acidic drugs are unionized according to the following simple equation: where A is an acidic drug and the excess hydrogen ions drive the equation to the left. In an alkaline environment, as in the small intestine and the majority of body fluids, basic drugs are unionized according to the following simple equation: where B is a basic drug and the deficit of hydrogen ions drives the equation to the right. Thus, acidic drugs are preferentially absorbed in the stomach and basic drugs are preferentially absorbed in the intestine.

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Because propranolol is extensively metabolized affected individuals show exaggerated and prolonged responses to this drug. Another example is the metabolism of isoniazid, a drug used to treat tuberculosis. This drug is metabolized by acetylation and can lead to toxic effects.

Often the condition is mediated by the immune system through inhalation of an antigen to which the individual is allergic. The antigen reacts with IgE attached to the mast cells in the lung causing the release of pharmacologically active mediators. These mediators include histamine and prostaglandins together with a range of other substances in small quantities (for example leukotrienes).

This is of particular significance in drugs administered orally and the oral dosage of such drugs must be reduced in older people. Older patients appear to be more at risk of developing drug-induced hepatitis particularly with the use of non-steroidal anti-inflammatory drugs. The principal organ of excretion for the majority of drugs is the kidney. The physiological functioning of this organ declines with age.

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