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Mirtazapine does cause sedation and weight gain. Trazodone antagonizes both pre-synaptic α-adrenergic and post-synaptic It has sedative properties and causes fewer anti-cholinergic side effects than the tricyclics. Monoamine oxidase inhibitors are drugs that irreversibly inhibit the action of the enzyme monoamine oxidase.

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Archived from the original on 29 January Canadian Journal of Clinical Pharmacology. The Drug Classroom. Archived from the original on 20 July. Men and women are equally likely to use benzodiazepines recreationally.


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It is quite likely that legislation will change in the future to allow other health care professionals to train to become independent prescribers. In summary, supplementary prescribing is likely to be most suitable with patients who have chronic conditions and can be managed by a supplementary prescriber between reviews by the doctor. That is, providing the supplementary prescriber is competent to manage the patients condition and there is a close working relationship between the independent prescriber and the supplementary prescriber who can share the same patient records. Supplementary prescribing would not be appropriate in emergency, urgent or acute conditions because a CMP has to be agreed before prescribing can begin.

Cardiac output also depends on end systolic volume, which in turn depends on afterload. Afterload is a function of total peripheral vascular resistance and blood pressure. If afterload becomes greater, ESV increases and cardiac output is reduced. As this happens, the EDV also increases and it follows that there is an increase in the force of contraction to restore cardiac output. In either case, the increase in force of contraction results in an increase in cardiac work and oxygen consumption. The basic rhythm of heart rate is maintained by a part of the heart known as the pacemaker or sinoatrial node.

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Particular areas of the central nervous system affected are the optic nerves, brain stem and cerebellum, corticospinal tracts of the spinal cord and areas around the ventricles. Demyelination leads to variable symptoms depending on where the lesions are.

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