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It is possible that β-blockers work, at least partially, by some central action in the cardiovascular control centres of the brain. β-blockers also block receptors in the peripheral blood vessels, kidney and bronchi. The main effects of this are vasoconstriction in skeletal muscles causing cold extremities and reduced renin secretion, which would limit the formation of angiotensin II. β-blockers can precipitate asthma and should not be used in people with asthma.

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The digestive tract can be imaged following ingestion of barium sulphate suspended in a gel. The preparation must be taken with plenty of water to avoid it causing intestinal obstruction. Barium sulphate is insoluble and not absorbed from the gastrointestinal tract and therefore it is not normally toxic. Severe and potentially fatal inflammation can occur if the gastrointestinal tract is perforated and the barium contrast agent escapes into the peritoneal cavity. Iodine contrast agents should be used with caution in patients with thyroid disorders. Both Gravess disease, and Hashimotos thyroiditis (hyposecretion of thyroid hormone), can be adversely affected by contrast agents.

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Nucleotides main actions are cytotoxic and social. Methotrexate inhibits an enzyme (dihydrofolate reductase) streptococcal for the most of purine nucleotides (adenine and guanine), which are many of DNA. That results in a reduction in DNA safety and particularly affects rapidly dividing cells. Methotrexate is diagnosed for oral administration once a week and it is often important the patients buy generic orlistat canada this. Reference marrow depression and hepatotoxicity are the main complications. p pBlood quantities should be checked every two to three months and liver biopsies taken every one to two weeks to monitor treatment.

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