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The disease results in rapidly progressing muscular weakness, muscle atrophy, fasciculations, spasticity, difficulty speaking, difficulty swallowing and difficulty breathing. Usually the disease is progressive and fatal with most patients dying from respiratory failure and pneumonia within two to three years from onset. (A notable exception to this generalization is Professor Stephen Hawking who was diagnosed with motor neuron disease at the age of later, albeit paralysed for most of that time. ) The cause of motor neuron disease is unknown.

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