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A damaged cell may be repaired and if that fails, the cell would normally self-destruct by a process known as apoptosis. Apoptosis is genetically programmed cell destruction that removes old, redundant and abnormal cells. This guards against mutations surviving and cells becoming malignant. Many cytotoxic anti-cancer drugs damage DNA and initiate apoptosis. Loss or mutation of tumour suppressor genes allows cells to undergo malignant transformations.

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This leads to increased amounts of acetylcholine available to interact with remaining receptors and so improves the ability of muscles to contract. An example of an anticholinesterase drug is pyridostigmine.

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