Zaleplon is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class. Sonata is indicated for the short-term treatment of insomnia. The dose of Sonata should be individualized. The recommended dose of Sonata for most nonelderly adults is 10 mg. For certain low weight individuals, 5 mg may be a sufficient dose. Doses above 20 mg have not been adequately evaluated and are not recommended.

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Zaleplon is used to treat insomnia trouble sleeping. Zaleplon will help you get to sleep faster and sleep throughout the night. In most cases, sleep medicines should only be used for short periods of time, such as 1 or 2 days, and generally for no longer than 1 or 2 weeks. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Safety and efficacy have not been established.

It is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class. Zaleplon is slightly effective in insomnia, 3 clarification needed zaleplon 10 mg oral capsule characterized by difficulty falling asleep. Zaleplon significantly reduces the time required to fall asleep by improving sleep latency and may therefore facilitate sleep induction rather than sleep maintenance. Zaleplon is not recommended for chronic use in the elderly. Zaleplon may increase the risk of injury among the elderly.

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Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Ask your doctor if you have any questions. Take zaleplon just before going to bed or when you have trouble falling asleep. This medicine works very quickly to put you to sleep. Do not take this medicine when your schedule does not permit you to get a full night's sleep about 7 to 8 hours.

Zaleplon may cause serious or possibly life-threatening sleep behaviors. After they woke up, these people were unable to remember what they had done. These activities may occur with zaleplon whether or not you drink alcohol or also take other sleep medications. Tell your doctor if you have ever had an unusual sleep behavior while taking zaleplon. Zaleplon is used on a short-term basis to treat insomnia difficulty falling asleep.

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Eventually a drug will be excreted from the body. This usually occurs via the kidneys, although some drugs can be lost in faeces or exhaled air. This chapter discusses the processes of administration, absorption, distribution, metabolism and excretion of drugs together with factors affecting these processes. Collectively, these processes describe drug disposition, the way in which the body handles drugs. The study of the fate of drugs in the body is known as pharmacokinetics. In order to get to their site of action in the body, drugs have to be administered in some way.

A decrease in heart rate and force of contraction would reduce cardiac output, but this is likely to be compensated for by the baroreceptor reflex. It is possible that β-blockers work, at least partially, by some central action in the cardiovascular control centres of the brain. β-blockers also block receptors in the peripheral blood vessels, kidney and bronchi. The main effects of this are vasoconstriction in skeletal muscles causing cold extremities and reduced renin secretion, which would limit the formation of angiotensin II. β-blockers can precipitate asthma and should not be used in people with asthma.

Large molecules such as vaccines, insulin and dextrans can provoke immune reactions themselves but most drugs are too small to be antigenic on their own. In some patients, something that cannot be predicted is that a drug or drug metabolite can combine with tissue proteins to form an antigenic conjugate. In this situation, the patient shows a response, which can be described under one of the classical definitions of allergic response (that is, type see below). Such reactions require initial exposure to the drug to cause sensitization, after which, subsequent exposure to the same drug triggers an immunological reaction. Although drug allergy is unpredictable, it is more likely to occur in individuals with a history of atopic disease, for example asthma.

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