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White, elliptical, biconvex film-coated tablets with a score-line on one side. The tablet can be divided into equal halves. Use the lowest effective dose. Zimovane should be taken in a single intake and not be re-administered during the same night. The recommended dose is one Zimovane tablet 7. A lower dose of 3.
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In addition, the relevant body, as set out in the legislation, must authorize the PGD. In practice, Clinical Governance Leads are likely to be appropriate, but they can only do so as named individuals. The information that must be contained in all PGDs is listed below: Name of the business to which the direction applies; Date the direction comes into force and the date it expires; Description of the medicine(s) to which the direction applies; Class of health professional who may supply or administer the medicine; Signature of a doctor and a pharmacist; Signature on behalf of an appropriate organization; Clinical condition or situation to which the direction applies; Description of those patients excluded from treatment under the direction; Description of the circumstances in which further advice should be sought from a doctor, and arrangements for referral; Details of appropriate dosage and maximum total dosage, quantity, pharmaceutical form and strength, route and frequency of administration, and minimum or maximum period over which the medicine should be administered; Relevant warnings, including potential adverse reactions; Details of any necessary follow-up action; and the circumstances; Statement of the records to be kept for audit purposes. Examples of PGDs relevant to podiatric surgery are shown in Appendix C. Podiatrists are already exempt from certain requirements of the Medicines Act.
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The half-life of acitretin is about two days. However, there is a high risk of teratogenesis and women must use adequate contraception and stop treatment for two years before conception.
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Only specific professional groups can work within a PGD, including radiographers, paramedics, nurses, podiatrists, physiotherapists, speech therapists and pharmacists. If a non-permitted professional group uses a PGD then they will break the law.
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Examples of individual drugs have been kept to a minimum in the text, with usually just one or two examples given in each section. It would be impractical to try to remember the names of all drugs available.
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Hyperplasia of the gums and hirsutism can occur. Hypersensitivity reactions, usually skin rashes, are quite common while hepatitis, which can be severe and lymph node enlargement are less common. Increased incidence of fetal malformation, particularly cleft palate and cardiac malformation is suspected in epileptic mothers who take phenytoin. Carbamazepine appears to have similar pharmacological action to phenytoin. It is particularly useful in treating psychomotor epilepsy.
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The most common side effects of imidazoles are irritation and itching of the skin.
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