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The oral route is the most commonly used for systemic effect because it is convenient and generally acceptable to patients and requires no special skills. Absorption of a drug from the gastrointestinal tract is normally by diffusion and depends on many factors including lipid solubility and pH of the gastrointestinal contents. Once absorbed into the blood stream, a drug is distributed around the body.
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- However, relapse is very common, usually within six months of stopping therapy.
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Describe the mechanism by which the problem arises. In medicinal use, drugs are usually administered with the best of intentions, which is to have a beneficial therapeutic effect.
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