Bupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake of the neurotransmitters norepinephrine and dopamine from the synaptic cleft, therefore prolonging their duration of action within the neuronal synapse and the downstream effects of these neurotransmitters. When used as an aid to smoking cessation, bupropion is thought to confer its anti-craving and anti-withdrawal effects by inhibiting dopamine reuptake, which is thought to be involved in the reward pathways associated with nicotine, and through the antagonism of the nicotinic acetylcholinergic receptor. Bupropion is sometimes used as an add-on agent to first-line treatments of depression such as selective serotonin reuptake inhibitor SSRI medications when there is a treatment-failure or only partial response. This includes the hypothalamus, which is involved in appetite regulation, and the mesolimbic dopamine circuit, which is involved in reward pathways. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Bupropion is indicated for the treatment of major depressive disorder MDD, seasonal affective disorder SAD, and as an aid to smoking cessation. Bupropion is also used off-label as a first-line treatment in patients with ADHD and comorbid bipolar disorder when used as an adjunct to mood stabilizers.

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The safety and efficacy of bupropion is not established in pediatric patients less than 18 years of age. Children 6 years and older with a major depressive episode or attention deficit hyperactivity disorder ADHD have been studied in clinical trials of bupropion, but data regarding pediatric safety are limited. Careful screening and monitoring is recommended by the American Heart Association if bupropion is used in pediatric patients. The difference in absolute risk of suicidal thoughts and behaviors across different indications was highest in those with major depression. Nevertheless, the need for an antidepressant in children, adolescents, or young adults for any use must be weighed against the risk of suicidality; it is unknown if this risk extends to long-term use. All patients should be monitored for symptom worsening or suicidality, especially at treatment initiation or after dose changes. A change to the treatment regimen or discontinuation of bupropion may be necessary in patients with emerging suicidality or worsening depression. Initially, mg PO twice daily; titrate after no less than 3 days to mg PO 3 times per day if needed; no single dose should exceed mg. The onset of antidepressant effects takes 1 to 3 weeks, maximal effect may not be noted for 4 weeks. Use the lowest dosage that maintains remission.

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Bupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake of the neurotransmitters norepinephrine and dopamine from the synaptic cleft, therefore prolonging their duration of action within the neuronal synapse and the downstream effects of these neurotransmitters. The risk or severity of adverse effects can be increased when 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline is combined with Bupropion.

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Bupropion zyban 300 mg to the family of medications known as antidepressants. It is used in addition to counselling, as an aid for quitting smoking. It may also be used with nicotine replacement products. In general, nicotine replacement therapy alone should be tried before using bupropion. Bupropion works by affecting the balance of chemicals that occur naturally in the brain.

The safety and efficacy of bupropion is not established in pediatric patients less than 18 years of age. Oral Route.

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Or in a crisis, text NAMI to All FDA black box warnings are at the end of this fact sheet. Bupropion is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder MDD, seasonal affective disorder SAD, and to help people quit smoking smoking cessation. SAD is a type of depression that occurs mainly during the autumn-winter season.

It is recommended that treatment is started while the patient is still smoking and a target stop date set within the first two weeks of treatment with Zyban, preferably in the second week. The initial dose is mg to be taken daily for six days, increasing on day seven to mg twice daily. The maximum single dose must not exceed mg and the maximum total daily dose must not exceed mg. Insomnia is a very common adverse event which can be reduced by avoiding bedtime doses of Zyban provided there is at least 8 hours between doses. Use in patients under 18 years of age is not recommended as the safety and efficacy of Zyban tablets have not been evaluated in these patients.

Thomas A. Barringer, MD Elizabeth M. Sustained release bupropion for pharmacologic relapse after smoking cessation. Ann Intern Med ; The investigators studied whether continuing bupropion treatment after initial success would decrease the relapse rate.

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